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Spravato (Esketamine)

SPRAVATO® is the first nasal spray medication specifically for adults with treatment-resistant depression

Studied in adults with treatment-resistant depression and taken with a daily oral antidepressant

Greater reduction of depressive symptoms at four weeks‡ (compared to those who received a placebo and oral antidepressant)

Nasal spray you self-administer under the supervision of a healthcare professional

In clinical trials, after 16 weeks of therapy, patients who stayed on SPRAVATO®† were less likely to experience a return of depressive symptoms than those who stopped therapy

After you take SPRAVATO®, a healthcare provider will monitor you for at least two hours during the observation period for possible serious side effects

Along with an oral antidepressant.

In clinical trials of adults who took SPRAVATO® and an oral antidepressant compared to those who received a placebo and an oral antidepressant. Based on an overall score on a standardized rating scale.


Most frequent questions and answers

Please call your insurance company and ask if treatment with Spravato (esketamine) is covered.

The manufacturer of Spravato (Janssen) also provides assistance for patients in determining insurance coverage and may also be able to provide some financial support for your treatment.

Please call the Janssen CarePath Program at 844-777-2828

If you are covered then please call our practice at 817-381-9650 to make an appointment.

Our office will schedule you for an evaluation as soon as possible to assess your case and determine whether Spravato (esketamine) is the next best treatment for your case of TRD. We will also discuss what other treatment options should be considered for you in that regard.

Your first treatment session for administration of the intranasal treatment with Spravato will be scheduled promptly if Spravato (esketamine) is the right treatment for you.

Each visit to the office for treatment will take about two and a half hours.

First your dose of Spravato is administered in the doctor’s office.

Next there is a 2 hour safety monitoring period. During this time your blood pressure will be monitored. You will also be checked for any sedation and presence of any dissociative symptoms (feeling strange, disconnected transiently) or any other side effects.

After 2 hours, if you are stable then you will then be discharged home. You will need somebody to drive you home after the treatment.

These include transient sedation, a possible rise in your blood pressure and feelings of dissociation (such feeling strange, disconnected or change in sense of time). These side effects may typically be present for the first 2 hours after taking the nasal spray of ketamine. For this reason you are monitored in the doctor’s office for a period of 2 hours after your dose of Spravato (esketamine). Such side effects if they occur typically go away the same day.

During this time your blood pressure will be checked periodically and you will be assessed for the presence of any specific side effects. After 2 hours the doctor will assess you clinically to make sure you are safe to be discharged home.

For the first 4 weeks you come in twice per week, each time for a two and a half hour visit.

In the second month your visits are now once per week.

After that treatments for long term maintenance with Spravato (esketamine) might be once per week or twice per month depending on your clinical course.

We will work with your insurance company to cover this service

We accept most insurances and will try to get it authorized.

Some or all of the following charges may be covered by your insurance.

The initial evaluation for 70 minutes is $350. Each visit for Spravato (esketamine) treatment administration (2.5hrs) costs $400 if not covered by insurance.

Payment is due at the time of service.

This is prohibited by the FDA as ketamine has the potential to be abused and therefore lead to addiction. Therefore, administration is solely at the doctor’s office.

Is SPRAVATO® right for you?

If you’ve struggled with depression and tried two or more antidepressants in your current episode without adequate relief, talk to our certified healthcare provider to see if Spravato® can help with your symptoms.